Zotarolimus

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Zotarolimus

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

221877-54-9

包装与价格：

包装	价格(元)
2mg	电议
5mg	电议
10mg	电议
25mg	电议
10mM * 1mL in DMSO	电议

产品名称

A 179578, ABT 578, Resolute, 42-(1-Tetrazolyl)rapamycin

产品介绍

生物活性

Zotarolimus是一种免疫抑制剂，可以抑制FKBP-12结合的IC50为2.8nM。。它是雷帕霉素的半合成衍生物。它设计用于以磷酸胆碱为载体的支架。

靶点信息

FKBP-12
2.8 nM

化学数据

目录号	A11950
作用机制	Inhibitor (抑制剂)
M. Wt	966.21
Formula	C52H79N5O12
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	221877-54-9
Synonyms	A 179578, ABT 578, Resolute, 42-(1-Tetrazolyl)rapamycin
SMILES	C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@@H]([C@@H](C4)OC)N5C=NN=N5)C)/C)O)OC)C)C)/C)OC

溶解度

In vitro	DMSO	89 mg/mL (92.11 mM)
	Water	Insoluble
	Ethanol	89 mg/mL (92.11 mM)
<1 mg/ml means slightly soluble or insoluble. Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	10.35 mL	51.75 mL	103.5 mL
0.5 mM	2.07 mL	10.35 mL	20.7 mL
1 mM	1.03 mL	5.17 mL	10.35 mL
5 mM	0.21 mL	1.03 mL	2.07 mL

*The above data is based on the productmolecular weight 966.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.