ML-210 (ML210; CID49766530) is a novel, potent, selective RAS inhibitor, and also a covalent inhibitor of glutathione peroxidase 4 (GPX4) with anticancer activity. It inhibits GPX4 with an EC50 of 30 nM. ML-210 binds the GPX4 selenocysteine residue. ML-210 displayed nanomolar potency in the primary screening cell line while maintaining selectivity similar to previously identified probes. The probe is in a novel structural class in the field of RAS synthetically lethal compounds and will, therefore, be highly useful in identifying pathways that can potentially be used for selectively inhibiting cancer cells.

纯度：≥98%

CAS：1360705-96-9