CAS NO: | 141750-63-2 |
规格: | 98% |
分子量: | 403.5 |
包装 | 价格(元) |
500ug | 电议 |
1mg | 电议 |
5mg | 电议 |
Background:
Pitavastatin lactone is a major phase 2 metabolite of pitavastatin , an inhibitor of HMG-CoA reductase, that is found in plasma of rats and humans following oral administration., Pitavastatin lactone is formed when pitavastatin undergoes glucuronidation by the UDP-glucuronysyl transferases UGT1A1, UGT1A3, or UGT2B7 to form pitavastatin glucuronide, which then undergoes non-enzymatic conversion to pitavastatin lactone. It can be converted back to pitavastatin via hydrolysis.