Humanin is a neuroprotective peptide.
CAS：330936-69-1
分子式：C119H204N34O32S2
分子量：2687.2
纯度：98%
存储：Store at -20°C

Background:

Humanin is a neuroprotective peptide. It completely blocks amyloid-β (1-42) (Aβ42) and Aβ43-induced cell death of primary cortical neurons when used at a concentration of 10 μM. Humanin also prevents amyloid precursor protein (APP) antibody-induced cell death and reduces neurotoxicity in FH11 cells induced by the APP mutants A617G-APP, L648P-APP, V642I-APP, and NL-APP, which are associated with familial Alzheimer's disease (IC50s = 0.1-1 μM). In vivo, humanin (0.375 mg/kg per hour) increases systemic insulin sensitivity and enhances glucose uptake in skeletal muscle of rats.