您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > Amlodipine Besylate
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Amlodipine Besylate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Amlodipine Besylate图片
CAS NO:111470-99-6
包装:50mg
规格:98%
市场价:579元
分子量:567.05

产品介绍
Block of L-type calcium channel
CAS:111470-99-6
分子式:C20H25ClN2O5.C6H6O3S
分子量:567.05
纯度:98%
存储:Store at -20°C

Background:

Amlodipine besylate is a long-acting Ca2+ channel blocker that reduce blood pressure as an antihypertensive drugs.


Calcium channel is an ion channel that selectively permeable to calcium ions. It serves vital functions in cellular signal transduction.


In cortical neurons, treatment of amlodipine besylate (<= 5 um) rescued the viability of H(2) O(2) injured cell and elevated the free radicals levels. Amlodipine besylate exhibits neuroptorective effects, such as reducing oxidative stress, promoting survival signals and blocking death signals. [1] It also showed proliferative effect on human epidermoid carcinoma A431 cells.[2]


In patient with exertional angina, amlodipine besylate reduced the total peripheral resistance and myocardial oxygen demand. In cat orally treated with amlodipine besylate daily, the average indirect systolic blood pressure were decreased without significant body weight/serum creatinine/potassium concentrations changes. [3]


参考文献:
[1] Lee YJ, Park HH, Koh SH, Choi NY, Lee KY.  Amlodipine besylate and amlodipine camsylate prevent cortical neuronal cell death induced by oxidative stress.  J Neurochem.  2011 Dec;119(6):1262-70. doi: 10.1111/j.1471-4159.2011.07529.x.
[2] Yoshida J, Ishibashi T, Nishio M.  Antiproliferative effect of Ca2+ channel blockers on human epidermoid carcinoma A431 cells.  Eur J Pharmacol. 2003 Jul 4;472(1-2):23-31. 
[3] Henik RA, Snyder PS, Volk LM.  Treatment of systemic hypertension in cats with amlodipine besylate.  J Am Anim Hosp Assoc. 1997 May-Jun;33(3):226-34.