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NPC-15437(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NPC-15437(hydrochloride)图片
CAS NO:141774-20-1
规格:98%
分子量:511.6
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
NPC-15437 is a selective protein kinase C (PKC) inhibitor (IC50 = 19 uM).
CAS:141774-20-1
分子式:C25H50N4O2.2HCl
分子量:511.6
纯度:98%
存储:Store at -20°C

Background:

NPC-15437 is a selective protein kinase C (PKC) inhibitor (IC50 = 19 uM). It competitively inhibits phorbol ester- (Ki = 5 uM) and phosphatidylserine-induced (Ki = 12 uM) PKC activity but does not affect the activity of cAMP-dependent or Ca2+/calmodulin-dependent protein kinases. PKC signaling is involved in learning and memory, and when NPC-15437 was administered after Y maze training (0.1-10 mg/kg i.p.), it led to memory retention deficits in mice.