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Edotecarin(J 107088)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Edotecarin(J 107088)图片
CAS NO:174402-32-5
规格:98%
分子量:608.55
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Edotecarin是一种有效的topoisomeraseI抑制剂,可诱导单链DNA断裂,IC50值为50nM。
CAS:174402-32-5
分子式:C29H28N4O11
分子量:608.55
纯度:98%
存储:Store at -20°C

Background:

Edotecarin is a potent inhibitor of topoisomerase I that can induces single-strand DNA cleavage, with IC50 of 50 nM.


In the presence of human colon cancer cells labeled with 3Hthymidine, edotecarin (0.6 μmol/L) increases the formation of DNA-protein complexes in a time-dependent manner[1].


Edotecarin produces an 83% increase in survival in mice bearing intracranial D-456MG glioma and shows a strong antimetastatic effect[1]. Edotecarin results in tumor growth delays ranging from 10.45 days at the lowest dose (3 mg/kg) to 24.83 days at the highest (100 mg/kg). Combination treatment of edotecarin plus irinotecan improves antitumor activity in vivo compared with either agent alone[2].


[1]. Saif MW, et al. Edotecarin: a novel topoisomerase I inhibitor. Clin Colorectal Cancer. 2005 May;5(1):27-36. [2]. Ciomei M, et al. Antitumor efficacy of edotecarin as a single agent and in combination with chemotherapy agents in a xenograft model. Clin Cancer Res. 2006 May 1;12(9):2856-61.