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Gap 26
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Gap 26图片
CAS NO:197250-15-0
规格:98%
分子量:1550.79
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Gap junction blocker peptide, mapping to connexin 43 residue 63-75
CAS:197250-15-0
分子式:C70H107N19O19S
分子量:1550.79
纯度:98%
存储:Store at -20°C

Background:

Gap26 (Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg) is a connexin mimetic peptide, corresponding to residues 63-75 of connexin 43, which is a gap junction blocker.


Connexins, or gap junctions, are a family of structurally-related transmembrane proteins. Gap junctions contain channels that allow the passage of ions and small molecules between adjacent cells molecules. Calcium and inositol phosphates are among the second messengers that can pass through gap junction channels. [1] It was showed that gap26 attenuates rhythmic contractile activity of rabbit arterial smooth muscle (IC50 = 28.4 mM). It also blocks movement of IP3-induced ATP and Ca2+across connexin hemichannels, i.e. hexameric channels yet to dock with partners in aligned cells and to generate the gap junction cell–cell conduit. [2]


参考文献:
1. Boitano, S. and H. Evans Am. J. Physiol. Lung Cell Mol. Physiol. 279, L623 (2000).
2. T. Desplantez, V. Verma, L. Leybaert, W.H. Evans, R. Weingart, Gap26, a connexin mimetic peptide, inhibits currents carried by connexin43 hemichannels and gap junction channels, Pharmacological Research, Volume 65, Issue 5, May 2012, Pages 546-552.