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Ganglioside GM1 Asialo Mixture
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ganglioside GM1 Asialo Mixture图片
CAS NO:71012-19-6
规格:98%
分子量:1255.6
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
Ganglioside GM1 asialo is a component of cellular lipid rafts and can be formed by the cleavage of the sialic acid residue from ganglioside GM1 by neuraminidase.
CAS:71012-19-6
分子式:C62H114N2O23 (for Sphingosine C18:1)
分子量:1255.6
纯度:98%
存储:Store at -20°C

Background:

Ganglioside GM1 asialo is a component of cellular lipid rafts and can be formed by the cleavage of the sialic acid residue from ganglioside GM1 by neuraminidase. Ganglioside GM1 asialo is a glycolipid receptor for P. aeruginosa flagellin and stimulates defensive responses in host cells, including extracellular ATP release, calcium mobilization, and ERK1/2 phosphorylation when stimulated by flagellin and an anti-ganglioside GM1 asialo antibody. The percentage of ganglioside GM1 asialo-positive natural killer (NK) and CD8+ T cells in lung is increased in a mouse model of respiratory syncytial virus (RSV) infection compared with healthy animals. Depletion of ganglioside GM1 asialo-positive NK and T cells reduces IFN-γ levels in the lung, reduces weight loss, and increases lung viral load in RSV-infected mice. Ganglioside GM1 asialo mixture contains ganglioside GM1 asialo molecular species with C18:1 and C20:1 sphingoid backbones.