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Doripenem
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Doripenem图片
CAS NO:148016-81-3
规格:98%
分子量:420.5
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议

产品介绍
Ultra-broad spectrum injectable antibiotic
CAS:148016-81-3
分子式:C15H24N4O6S2
分子量:420.5
纯度:98%
存储:Store at -20°C

Background:

Doripenem is a new member of the carbapenem class of beta-lactam antibiotics with broad-spectrum coverage of Gram-positive, Gram-negative and anaerobic pathogens.Target: AntibacterialDoripenem is an ultra-broad-spectrum injectable antibiotic. It is a beta-lactam and belongs to the subgroup of carbapenems. It was launched by Shionogi Co. of Japan under the brand name Finibax in 2005 and is being marketed outside Japan by Johnson & Johnson. It is particularly active against Pseudomonas aeruginosa. It is recommended that those allergic to doripenem or to any type of beta-lactam antibiotics such as cephalosporin or other Carbapenems not receive doripenem.Doripenem appears as crystalline powder anywhere from a white to somewhat yellowish colour.Doripenem is moderately soluble in water, slightly soluble in methanol, and virtually insoluble in ethanol. Doripenem is also solution in N,N-dimethylformamide. Doripenem's chemical configuration has 6 asymmetrical carbon atoms (6 stereocentres) and is most commonly supplied as one pure isomer. In terms of doripenem for injection, the crystallized powered drug can form a monohydrate when mixed with water. However, Doripenem has not been proven to possess polymorphism.


参考文献:
[1]. Anderson DL. Doripenem. Drugs Today (Barc). 2006 Jun;42(6):399-404.
[2]. Jones RN, et al. Doripenem (S-4661), a novel carbapenem: comparative activity against contemporary pathogens including bactericidal action and preliminary in vitro methods evaluations. J Antimicrob Chemother. 2004 Jul;54(1):144-54. Epub 2004 Jun 9.