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Entinostat(MS-275,SNDX-275)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Entinostat(MS-275,SNDX-275)图片
CAS NO:209783-80-2
规格:98%
分子量:376.4
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议

产品介绍
HDAC1 and HDAC3 inhibitor
CAS:209783-80-2
分子式:C21H20N4O3
分子量:376.4
纯度:98%
存储:Store at -20°C

Background:

Entinostat (also known as MS-275 or SNDX-275), a derivative of 2-aminophenyl benzamides, is a potent and orally-available inhibitor of histone deacetylases (HDACs), a family of enzymes associated with a variety of well-characterized cellular oncogenes and tumor suppressors, that potently inhibits class I HDACs, including HDAC1, HDAC3 and HDAC8, with values of 50% inhibition concentration IC50of 0.368 μM, 0.501 μM and 63.4 μM respectively. Entinostat has been widely investigated for the treatment of cancer, in which results have shown the in vitro anti-proliferative activity of entinostat in a wide range of human cancer cell lines, including breast, colon, lung, myeloma, ovary, pancreas, prostate and leukemia.


Reference


Hess-Stumpp H, Bracker TU, Henderson D, Politz O. MS-275, a potent orally available inhibitor of histone deacetylases--the development of an anticancer agent. Int J Biochem Cell Biol. 2007;39(7-8):1388-405. Epub 2007 Feb 16.


Hess-Stumpp H. Histone deacetylase inhibitors and cancer: from cell biology to the clinic. Eur J Cell Biol. 2005 Mar;84(2-3):109-21.