Background:

Wedelolactone is an inhibitor of IKK.

IkB kinase (IKK) complex contains the catalytic subunits IKKα and IKKβ, and the regulatory subunit IKKγ/NEMO. IKK, is a kinase critical for activation of NF-κB by mediating phosphorylation and degradation of IκBα. The induction of caspase-11 is an important upstream controlling event in inflammatory response and apoptosis under pathological conditions modulated by upstream NF-κB-mediated transcription[1].

In vitro: In cultured mouse BALB/c 3T3 cells, mouse splenocytes and HeLa cells, wedelolactone (0