您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > Narasin(sodium salt)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Narasin(sodium salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Narasin(sodium salt)图片
CAS NO:58331-17-2
规格:98%
分子量:787
包装与价格:
包装价格(元)
5mg电议
25mg电议

产品介绍
ionophore antibiotic
CAS:58331-17-2
分子式:C43H71O11 ? Na
分子量:787
纯度:98%
存储:Store at -20°C

Background:

IC50: 3.2 μM: blocks NF-κB signaling via inhibition of IκBα phosphorylation


Narasin, isolated from certain Streptomyces sp. is an ionophore antibiotic. As a coccidiostat, it can be used in veterinary practice for gastrointestinal parasites. Narasin has been shown to induce tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-mediated apoptosis by ER stress in glioma cells and to dampen NF-κB signaling by suppressing the phosphorylation of IκBα. NF-κB, as a transcription factor, plays a vital role across many cellular processes which are involved in neuronal and embryonic development, cell proliferation, apoptosis, and immune responses to infection and inflammation.


In vitro: Narasin caused suicidal erythrocyte death or eryptosis. When human erythrocytes were exposed to narasin, it was shown that narasin resulted in the increase of annexin-V-binding indicating cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface and the decrease of forward scatter reflecting cell shrinkage, which indicated the death of erythrocyte [1]. Narasin blocked NF-κB signaling via inhibition of IκBα phosphorylation at a lower concentration [2].


In vivo: New Zealand White rabbits were given narasin 4-48 p. p. m, in pelleted feed. After 4 weeks, the experiments indicated that narasin protected rabbits from severe coccidiosis induced by E. flavescens, E. perforans E. magna, E. intestinalis, and E. stiedai. In addition, narasin reduced oocyst output in a highly effective fashion [3].


参考文献:
[1].  Bouguerra, G., Bissinger, R., Abbes, S., & Lang, F. Stimulation of Eryptosis by Narasin. Cellular Physiology and Biochemistry. 2015; 37(5):1807-1816.
[2].  Miller, S., Huang, R., Sakamuru, S., Shukla, S., Attene-Ramos, M., & Shinn, P. et al. Identification of known drugs that act as inhibitors of NF-κB signaling and their mechanism of action. Biochemical Pharmacology. 2010; 79(9): 1272-1280.
[3].  Peeters, J., Geeroms, R., Antoine, O., Mammerickx, M., & Halen, P. Efficacy of narasin against hepatic and intestinal coccidiosis in rabbits. Parasitology. 1981; 83(02): 293-301.