您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > Epiberberine
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Epiberberine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Epiberberine图片
CAS NO:6873-09-2
包装:10mg
规格:98%
市场价:3163元
分子量:336.12

产品介绍
BACE1 inhibitor
CAS:6873-09-2
分子式:C20H18NO4
分子量:336.12
纯度:98%
存储:Store at -20°C

Background:

IC50: 8.55 μM for BACE1


Epiberberine is a natural bioactive protoberberine alkaloid from Coptidis Rhizoma. Coptidis Rhizoma and its isolated alkaloids are found to possess a variety of activities including antioxidant and neuroprotective activities.


In vitro: Among six protoberberine alkaloids from Coptidis Rhizoma exhibiting predominant cholinesterases (ChEs) inhibitory effects, only epiberberine and groenlandicine exerted good, non-competitive BACE1 inhibitory activities with IC50 values of 8.55 and 19.68 μM, respectively, as compared with a positive control, quercetin. In addition, epiberberine also showed potent AChE and BChE inhibitory effects [1].


In vivo: In rats, epiberberine could parallelly shift the dose-response curves of Clo and BHT-920 to the normal without changing the maximal effect. The pA2 values of epiberberine were found to be 6.5 and 6.8 respectively. Epiberberine was also found to antagonize the contractile response of isolated rabbit aortic strips to Meth competitively. Epiberberine given to anesthetized rats intravenously was shown to be able to temporarily decrease blood pressure and gradually accelerate heart rate. The heart rate persistently and constantly increased in spite of blood pressure restoration. These results suggested epiberberine possessed poor α-blocking action [2].


Clinical trial: N/A


参考文献:
[1] Jung HA,Min BS,Yokozawa T,Lee JH,Kim YS,Choi JS. Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids. Biol Pharm Bull.2009 Aug;32(8):1433-8.
[2] Wang JL,Fang DC.  Effect of epiberberine on alpha-adrenoceptors. Yao Xue Xue Bao.1990;25(4):289-92.