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AGN 196996
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AGN 196996图片
CAS NO:958295-17-5
规格:98%
分子量:482.32
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
AGN 196996是高活性RARα选择性抑制剂,Ki为2 nM,对RARβ和RARγ的亲和性极低(Ki分别为1087 nM和8523 nM)。
CAS:958295-17-5
分子式:C24H20BrNO5
分子量:482.32
纯度:98%
存储:Store at -20°C

Background:

AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM).IC50 value: 2 nM(Ki)Target: RARα antagonistAGN 196996 shows no activity in transactivation assays, but instead block the gene transcriptional activity induced by ATRA and other RAR agonists.




[1]. Hammond LA, et al. Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells. Br J Cancer. 2001 Aug 3;85(3):453-62. [2]. Keedwell RG, et al. An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium. Br J Cancer. 2004 Aug 2;91(3):580-8.