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Protein degrader 1 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Protein degrader 1 hydrochloride图片
CAS NO:1448189-80-7
规格:98%
分子量:467.02
包装与价格:
包装价格(元)
100mg电议
500mg电议
1g电议
2g电议

产品介绍
Protein degrader 1 hydrochloride is used in the synthesis of HaloPROTACs.
CAS:1448189-80-7
分子式:C22H31ClN4O3S
分子量:467.02
纯度:98%
存储:Store at -20°C

Background:

Protein degrader 1 hydrochloride is used in the synthesis of HaloPROTACs.


Small molecule-induced protein degradation is an attractive strategy for the development of chemical probes.Protein degraders have the power to abrogate all of the functions of a drug target at once, including scaffolding functions which are difficult to target with small molecule inhibitors. A novel class of PROTACs that incorporate small molecule VHL ligands to successfully degrade HaloTag7 fusion proteins is developed. HaloPROTACs will inspire the development of future PROTACs with more drug-like properties. In HEK 293 cellsstably expressing GFP-HaloTag7,24 hour treatment with HaloPROTAC1 leads to less than 20% degradation, the longer HaloPROTAC2 leads to nearly 70% degradation of GFP-Halotag7 at 2.5 uM.HaloPROTACs containing protein degrader 1 leads to nearly 70% degradation of GFP-HaloTag7, when sufficiently long linkers are used[1].


参考文献:
[1]. Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins.ACS Chem Biol. 2015 Aug 21;10(8):1831-7.