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MZ1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MZ1图片
CAS NO:1797406-69-9
规格:98%
分子量:1002.6
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
MZ1 is a hybrid compound that drives the selective proteasomal degradation of bromodomain-containing protein 4 (BRD4).
CAS:1797406-69-9
分子式:C49H60ClN9O8S2
分子量:1002.6
纯度:98%
存储:Store at -20°C

Background:

MZ1 is a hybrid compound that drives the selective proteasomal degradation of bromodomain-containing protein 4 (BRD4). It is characterized as a proteolysis-targeting chimera (PROTAC) and contains JQ-1, which binds bromo- and extra-terminal (BET) proteins, linked to a ligand for the E3 ubiquitin ligase VHL. MZ1 induces the selective degradation of BRD4 in HeLa cells when used at 0.1-0.5 uM. At concentrations of 2-10 uM, MZ1 causes the removal of BRD2, BRD3, and BRD4. BRD protein removal is evident within four hours of adding MZ1 and persists for at least 48 hours, unless MZ1 is removed.