TH34

TH34 is a potent HDAC6/8/10 inhibitor
CAS：2196203-96-8
分子式：C15H16N2O2
分子量：256.305
纯度：98%
存储：Store at -20°C

Background:

TH34 is a potent HDAC6/8/10 inhibitor. TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines. The combination of TH34 with plasma-achievable concentrations of retinoic acid, a drug applied in neuroblastoma therapy, synergistically inhibits colony growth (combination index (CI) <?0.1 for 10 μM of each). In summary, our study supports using selective HDAC inhibitors as targeted antineoplastic agents and underlines the therapeutic potential of selective HDAC6/8/10 inhibition in high-grade neuroblastoma.

Reference

[1].Kolbinger FR, Koeneke E, Ridinger J, Heimburg T, Müller M, Bayer T, Sippl W,?Jung M, Gunkel N, Miller AK, Westermann F, Witt O, Oehme I. The HDAC6/8/10?inhibitor TH34 induces DNA damage-mediated cell death in human high-grade?neuroblastoma cell lines. Arch Toxicol. 2018 Aug;92(8):2649-2664. doi:?10.1007/s00204-018-2234-8. Epub 2018 Jun 9. PubMed PMID: 29947893; PubMed Central?
PMCID: PMC6063332.