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Thiamphenicol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Thiamphenicol图片
CAS NO:15318-45-3
包装:50mg
规格:98%
市场价:629元
分子量:356.22

产品介绍
antimicrobial antibiotic
CAS:15318-45-3
分子式:C12H15Cl2NO5S
分子量:356.22
纯度:98%
存储:Store at -20°C

Background:

Thiamphenicol is an antimicrobial antibiotic and a methyl-sulfonyl analogue of chloramphenicol.Target: AntibacterialThiamphenicol (also known as thiophenicol and dextrosulphenidol) is an antibiotic. It is the methyl-sulfonyl analogue of chloramphenicol and has a similar spectrum of activity, but is 2.5 to 5 times as potent. Like chloramphenicol, it is insoluble in water, but highly soluble in lipids. It is used in many countries as a veterinary antibiotic, but is available in China, Morocco and Italy for use in humans. Its main advantage over chloramphenicol is that it has never been associated with aplastic anaemia. Thiamphenicol is a derivative of chloramphenicol characterized by a spectrum comparable to that of the parent compound against multiresistant pathogens but showing satisfactory tolerability. Thiamphenicol showed a significant PAE (0.33 to 2.9h) on all pathogens studied and a powerful bactericidal effect against beta-lactamase-positive and -negative H. influenzae. These results indicate a good in vitro activity of thiamphenicol against difficult-to-treat multiply resistant pathogens [1, 2].


参考文献:
[1]. http://en.wikipedia.org/wiki/Thiamphenicol
[2]. Marchese, A., et al., In vitro activity of thiamphenicol against multiresistant Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in Italy. J Chemother, 2002. 14(6): p. 554-61.