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GSK503
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK503图片
CAS NO:1346572-63-1
规格:98%
分子量:526.67
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
EZH2 inhibitor
CAS:1346572-63-1
分子式:C31H38N6O2
分子量:526.67
纯度:98%
存储:Store at -20°C

Background:

GSK503 is a potent inhibitor of EZH2.


Enhancer of zeste homolog 2 (EZH2) is a histone-lysine N-methyltransferase enzyme that catalyses trimethylation of lysine 27 in histone 3 (H3K27me3), and then induces chromatin compaction and consequently inhibits target genes transcription.


GSK503 is a potent EZH2 inhibitor with anticancer activity. In human melanoma cells, GSK503 significantly reduced H3K27me3 levels, induced G1 cell cycle arrest and slowed down cell growth [1].


In mice, GSK503 induced reversible weight loss by