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RGD(Arg-Gly-Asp)Peptides
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
RGD(Arg-Gly-Asp)Peptides图片
CAS NO:99896-85-2
包装:10mg
规格:98%
市场价:844元
分子量:346.34

产品介绍
Inhibits integrin binding to RGD motifs
CAS:99896-85-2
分子式:C12H22N6O6
分子量:346.34
纯度:98%
存储:Store at -20°C

Background:

Synthetic peptides containing the arginine-glycine-aspartate (RGD) were extensively used as inhibitors of integrin-ligand interactions in studies of cell adhesion, migration, growth and differentiation, since the RGD motif is an integrin-recognition motif found in many ligands.


In vitro: RGD peptide can induce apoptosis in the absence of signals and integrin-mediated cell clustering. Previous study demonstrates that RGD peptides promote apoptosis through activation of conformation changes enhancing pro-caspase-3 activation and autoprocessing [1].


In vivo: Anima study suggested that the RGD-4C-FITC-peptide bound to both endothelial and tumor cells in vivo and that peptide targeting should allow the delivery of therapeutic drugs to both endothelial and tumor cells [2].


Clinical trials: Currenlty no clinical data are available.


参考文献:
[1] Nature.  1999 Feb 11;397(6719):534-9.
RGD peptides induce apoptosis by direct caspase-3 activation. 
Buckley CD1, Pilling D, Henriquez NV, Parsonage G, Threlfall K, Scheel-Toellner D, Simmons DL, Akbar AN, Lord JM, Salmon M. 
[2] Cancer Res.  2002 Sep 15;62(18):5139-43. Arginine-glycine-aspartic acid (RGD)-peptide binds to both tumor and tumor-endothelial cells in vivo.  Zitzmann S1, Ehemann V, Schwab M.