RWJ-445167是一种有效的thrombin和factorXa双重抑制剂,Ki值分别为4.0nM和230nM,具有抗血栓形成的作用。
CAS:226566-43-4
分子式:C18H24N6O5S
分子量:436.49
纯度:98%
存储:Store at -20°C
Background:
RWJ-445167 is a dual inhibitor of thrombin and factor Xa with Ki of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity.
[1]. RWJ-445167, et al. Exploration of potential prodrugs of RWJ-445167, an oxyguanidine-based dual inhibitor of thrombin and factor Xa. Chem Biol Drug Des. 2006 Jul;68(1):29-36.