SR121566A是一种新型的非肽GlycoproteinIIb/IIIa(GPIIb-IIIa)拮抗剂，可以抑制ADP，花生四烯酸和胶原诱导的人血小板集合，IC50s分别为46±7.5，56±6和42±3nM。
CAS：180144-61-0
分子式：C20H25N5O4S
分子量：431.51
纯度：98%
存储：Store at -20°C

Background:

SR121566A is a novel non-peptide Glycoprotein IIb/IIIa (GP IIb-IIIa) antagonist, which can inhibit ADP-, arachidonic acid- and collagen-induced human platelet aggregation with IC50s of 46±7.5, 56±6 and 42±3 nM, respectively.

SR121566A leads to dose-dependent increases in TTO, a statistically significant increase being observed at the doses of 0.3 mg/kg (473%) and 30 mg/kg (771%), respectively[2].

[1]. Herault JP，et al. Effect of SR121566A, a potent GP IIb-IIIa antagonist on platelet-mediated thrombin generation in vitro and in vivo. Thromb Haemost. 1998 Feb;79(2):383-8. [2]. Lorrain J, et al. Effects of SanOrg123781A, a synthetic hexadecasaccharide, in a mouse model of electrically induced carotid artery injury: synergism with the antiplatelet agent clopidogrel. J Pharmacol Exp Ther. 2004 Apr;309(1):235-40.