IKK-2 inhibitor,potent and selective
CAS：507475-17-4
分子式：C12H10FN3O2S
分子量：279.29
纯度：98%
存储：Store at -20°C

Background:

TPCA-1 is a novel, potent, and selective inhibitor of human IKK-2.

Demonstration that IκB kinase 2 (IKK-2) plays a pivotal role in the nuclear factor-κB-regulated production of proinflammatory molecules by stimuli such as tumor necrosis factor (TNF)-α and interleukin (IL)-1 suggests that inhibition of IKK-2 may be beneficial in the treatment of rheumatoid arthritis.

In vitro: Determination of the activity of TPCA-1 against ten selected kinases, COX-1 and COX-2, showed the compound to be