BPK-29是一种共价小分子化合物，破坏NR0B1复合物以及损害KEAP1突变癌细胞的锚定独立生长。
CAS：2143467-62-1
分子式：C26H32ClN3O3
分子量：470
纯度：98%
存储：Store at -20°C

Background:

BPK-29 is a covalent small molecule that disrupts NR0B1 complexes and impairs the anchorage-independent growth of KEAP1-mutant cancer cells[1].

BPK-29 substantially engages NR0B1 with good overall proteomic selectivity in KEAP1-mutant Non-Small Cell Lung Cancers[1].

[1]. Woodruff TM,et al. The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis. J Immunol. 2008 Dec 15;181(12):8727-34.