Dextrorphan is a phencyclidine-like metabolite of dextromethorphan , an antitussive found in cough medicines.
CAS：143-98-6
分子式：C17H23NO.C4H6O6
分子量：407.5
纯度：98%
存储：Store at -20°C

Background:

Dextrorphan is a phencyclidine-like metabolite of dextromethorphan, an antitussive found in cough medicines.[1] Dextrorphan, while also having antitussive activity, is psychoactive, leading to the abuse of cough medicines containing the parent compound.[1],[2] Dextrorphan antagonizes NMDA and μ-opioid receptors (Kis = 54 and 420 nM, respectively) and inhibits norepinephrine and serotonin transporters (Kis = 340 and 401 nM, respectively).[3],[4],[5] This product is intended for forensic and research applications.

Reference:
[1]. Shin, E.J., Lee, P.H., Kim, H.J., et al. Neuropsychotoxicity of abused drugs: Potential of dextromethorphan and novel neuroprotective analogs of dextromethorphan with improved safety profiles in terms of abuse and neuroprotective effects. Journal of Pharmacological Sciences 106(1), 22-27 (2008).
[2]. Chomchai, C., and Manaboriboon, B. Stimulant methamphetamine and dextromethorphan use among Thai adolescents: implications for health of women and children. J.Med.Toxicol. 8(3), 291-294 (2012).
[3]. LePage, K.T., Ishmael, J.E., Low, C.M., et al. Differential binding properties of [3H]dextrorphan and [3H]MK-801 in heterologously expressed NMDA receptors. Neuropharmacology 49(1), 1-16 (2005).
[4]. Kaczor, A.A., Kijkowska-Murak, U.A., and Matosiuk, S. Theoretical studies on the structure and symmetry of the transmembrane region of glutamatergic GluR5 receptor. Journal of Medicinal Chemistry 51(13), 3765-3776 (2008).
[5]. Codd, E.E., Shank, R.P., Schupsky, J.J., et al. Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: Structural determinants and role in antinociception. J. Pharmacol. Exp. Ther. 274(3), 1263-1270 (1995).