SRI31215(TFA)是一种matriptase、hepsin、肝细胞生长因子激活剂(HGFA)的三重抑制剂，IC50值分别为0.69μM、0.65μM、0.3μM，SRI31215通过阻断pro-HGF的活化，从而模拟了HAI-1/2的活性。
CAS：1832686-44-8
分子式：C27H34F3N5O3
分子量：533.59
纯度：98%
存储：Store at -20°C

Background:

SRI 31215 (TFA), a triplex inhibitor of matriptase, hepsin and hepatocyte growth factor activator (HGFA) with IC50s of 0.69 μM, 0.65 μM, 0.3 μM, blocks pro-HGF activation and thus mimics the activity of HAI-1/2[1]. IC50: 0.69 μM (matriptase), 0.65 μM (hepsin), 0.3 μM (HGFA)[1]

[1]. Owusu BY, et al. Inhibition of pro-HGF activation by SRI31215, a novel approach to block oncogenic HGF/MET signaling. Oncotarget. 2016 May 17;7(20):29492-506.