Deruxtecan 是 DS-8201 的连接体，是一种毒素，是连接桥与药物的偶联物，是抗体-药物偶联物 (ADC) 的一部分。详细信息请参考专利文献 WO2017002776A1 中的化合物 1。
CAS：1599440-13-7
分子式：C52H56FN9O13
分子量：1034.05
纯度：98%
存储：Store at -20°C

Background:

Deruxtecan, a toxin and linker moiety of DS-8201, is a drug-linker conjugate for antibody-drug conjugate (ADC) extracted from patent WO2017002776A1, compound 1. Drug-linker conjugates for ADC[1]

Antibody-drug conjugates deliver anticancer agents selectively and efficiently to tumor tissue and have significant antitumor efficacy with a wide therapeutic window[2].

[1]. NOGUCHI, Shigeru, et al. METHOD FOR SELECTIVELY MANUFACTURING ANTIBODY-DRUG CONJUGATE. WO2017002776A1. [2]. Ogitani Y, et al. Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody-drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity. Cancer Sci. 2016 Jul;107(7):1039-46.