PF-06459988是T790M-ContainingEGFRMutants不可逆性抑制剂。
CAS：1428774-45-1
分子式：C19H22ClN7O3
分子量：431.88
纯度：98%
存储：Store at -20°C

Background:

PF-06459988 is an irreversible inhibitor of T790M-Containing EGFR Mutants.

[1]. Cheng H, et al. Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants. J Med Chem. 2016 Mar 10;59(5):2005-24. doi: 10.1021/acs.jmedchem.5b01633. Epub 2016 Jan 28.