D77是一种抗HIV-1抑制剂,靶向作用于整合酶与细胞LEDGF/p75的相互作用,D77抑制HIV-1(IIIB)复制,作用于MT-4细胞时,EC50值为23.8μg/ml(C8166细胞时,EC50值为5.03μg/ml)。
CAS：497836-10-9
分子式：C28H22BrNO7S
分子量：596.45
纯度：98%
存储：Store at -20°C

Background:

D77 is anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75. D77 inhibits HIV-1(IIIB) replication by EC50 value of 23.8 μg/ml in MT-4 cell (5.03 μg/ml for C8166 cells).IC50 value: 23.8 μg/ml (EC50, in MT-4 cell ), 5.03 μg/ml (EC50, in C8166 cell)Target: HIV-1in vitro: D77 exhibits a highly specific binding affinity to HIV-1 integrase catalytic core domain.D77 induces a dramatic concentration-dependent decrease of α-galactosidase activity compared to the D77-untreated cells. D77 reveals a significant inhibition activity against the interaction of IN with IBD.

[1]. Du L, et al. D77, one benzoic acid derivative, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75. Biochem Biophys Res Commun. 2008 Oct 10;375(1):139-144.