CDC801是一种强效的磷酸二酯酶4(PDE4)和肿瘤坏死因子-α(TNF-α)抑制剂。IC50分别为1.1μM和2.5μM。
CAS：192819-27-5
分子式：C23H24N2O5
分子量：408.45
纯度：98%
存储：Store at -20°C

Background:

CDC801 is a potent and orally active phosphodiesterase 4 (PDE4) and tumor necrosis factor-α (TNF-α) inhibitor with IC50 of 1.1 μM and 2.5 μM, respectively.

The more detailed information refer to the Compound 6b in the reference 1 (PMID:19256507)[1].

[1]. Man HW, et al. Discovery of (S)-N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl] acetamide (apremilast), a potent and orally active phosphodiesterase 4and tumor necrosis factor-alpha inhibitor. J Med Chem. 2009 Mar 26;52(6):1522-4.