p53 activator
CAS：1011301-27-1
分子式：C18H21N3OS
分子量：327.44
纯度：98%
存储：Store at -20°C

Background:

Tenovin SAR Studies Aimed at Increasing Water Solubility

ID			p53 Increasea	K40Ac Tubulin Increaseb	SirT2 Inhibitionc
	R1	R2
Tenovin-1	tBu	NHCOCH3	+	+	+
Tenovin-2	tBu	NHCOCH(CH3)2	+	+	+
Tenovin-3	tBu	NH2	+	+	+
Tenovin-4	N3	NHCOCH3	−	−	−
Tenovin-5	tBu	NHCOPh	+	+	+
Tenovin-6	tBu	NHCO(CH2)4NMe2.HCl	+	+	+

• a     Ability to increase p53 levels was determined in MCF-7 cells treated for 6 hr at 10 μM.

• b     Ability to increase K40 Ac-tubulin levels was determined in H1299 cells treated

• c     SirT2 inhibition assessed using a compound concentration of 10 or 30 μM depending on the compound's solubility in the assay buffer.