您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > Valeroyl Salicylate
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Valeroyl Salicylate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Valeroyl Salicylate图片
CAS NO:64206-54-8
规格:98%
分子量:222.2
包装与价格:
包装价格(元)
100mg电议
500mg电议
1g电议

产品介绍
selective, irreversible inhibitor of cyclooxygenase-1 (COX-1)
CAS:64206-54-8
分子式:C12H14O4
分子量:222.2
纯度:98%
存储:Store at -20°C

Background:

Valeroyl Salicylate is an irreversible and selective inhibitor of cyclooxygenase-1 (COX-1) with IC50 values of 0.8 and 15 mM for ovine COX-1 and -2, respectively [1].


Cyclooxygenase (COX), also known as prostaglandin-endoperoxide synthase (PTGS, PGHS), is an enzyme responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. COX-1 is the constitutive isoform and is mainly responsible for the synthesis of cytoprotective prostaglandins in the gastrointestinal tract (GI) and of the proaggregatory thromboxane in blood platelets. COX-2 is inducible and short-lived that is stimulated by endotoxin, cytokines, and mitogens. COX-2 plays important roles in prostaglandin biosynthesis in inflammatory cells the central nervous system [1][2].


Valeroyl Salicylate is an irreversible and selective inhibitor of cyclooxygenase-1 (COX-1) with IC50 values of 0.8 and 15 mM for ovine COX-1 and -2, respectively. In cos-1 cells expressing either COX-1 or -2, 500 μM of valeroyl salicylate inhibited human COX-1 and -2 by 85% and 15%, respectively. The half-lives for inactivation of human recombinant COX-1 in the presence of 500 μM valeroyl salicylate was 12 minutes [2].


参考文献:
[1].  Johnson JL, Wimsatt J, Buckel SD, et al. Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons. Arch Biochem Biophys. 1995 Dec 1;324(1):26-34.
[2].  Bhattacharyya DK, Lecomte M, Dunn J, et al. Selective inhibition of prostaglandin endoperoxide synthase-1 (cyclooxygenase-1) by valerylsalicylic acid. Arch Biochem Biophys. 1995 Feb 20;317(1):19-24.