C-11 是一种基于 tubulysin，用于抗体-药物偶联物 (ADCs) 的药物 -linker 连接物，对癌细胞具有细胞毒性。
CAS：2007965-97-9
分子式：C38H58N6O7S
分子量：742.97
纯度：98%
存储：Store at -20°C

Background:

C-11 is a tubulysin-based drug-linker conjugate for ADC, displays cytotoxicity for carcinoma cell lines[1].

C-11 exhibits cytotoxicity for N87 cells and MDA-MB-361-DYT2 cells with IC50s of 1.11 nM and 0.9 nM, respectively[1].

[1]. Leverett CA, et al. Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads. ACS Med Chem Lett. 2016 Aug 26;7(11):999-1004.