KHK-IN-1盐酸盐是己酮糖激酶(KHK)高效抑制剂,IC50值12nM。
CAS：1303470-48-5
分子式：C21H27ClN8S
分子量：459.01
纯度：98%
存储：Store at -20°C

Background:

KHK-IN-1 Hcl is a potent ketohexokinase (KHK) inhibitor with IC50 of 12 nM, interacts with Asp-27B in the ATP-binding region of KHK.

[1]. Maryanoff BE, et al. Pyrimidinopyrimidine inhibitors of ketohexokinase: exploring the ring C2 group that interacts with Asp-27B in the ligand binding pocket. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5326-9. [2]. Maryanoff BE, et al. Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site. ACS Med Chem Lett. 2011 Apr 18;2(7):538-43.