Microcystin-LR 是蛋白磷酸酶 1 型和 2A 型 (PP1/2A) 的有效抑制剂，其 IC50 值分别为 1.7 nM，0.04 nM。
CAS：101043-37-2
分子式：C49H74N10O12
分子量：995.17
纯度：98%
存储：Store at -20°C

Background:

Microcystins are hepatotoxic cyclic heptapeptide toxins produced by cyanobacteria.[1] They are responsible for periodic poisonings of humans and livestock drinking fresh water where the blue-green algae are endemic. Microcystin-LR is a selective inhibitor of protein phosphatase 2A (PP2A) (IC50= 0.04 nM) and will completely inhibit this enzyme without affecting PP1 when used at a concentration of 0.5 nM.[2] The PP1 IC50 is about 1.7 nM. Microcystins are at least 10 times more potent as serine/threonine PP inhibitors than okadaic acid, another microalgal toxin also used for this purpose.

Reference:
[1]. Rinehart, K.L., Harada, K.-i., Namikoshi, M., et al. Nodularin, microcystin, and the configuration of Adda. J. Am. Chem. Soc. 110, 8557-8558 (1988).
[2]. Honkanen, R.E., Zwiller, J., Moore, R.E., et al. Characterization of microcystin-LR, a potent inhibitor of Type 1 and Type 2A protein phosphatases. The Journal of Biological Chemisty 265(32), 19401-19404 (1990).