T-26c是高效和选择性的基质金属蛋白酶-13(MMP-13)抑制剂，IC50值为6.75pM。比对其他相关金属酶的选择性高2600倍。
CAS：869296-13-9
分子式：C24H21N3O6S
分子量：479.51
纯度：98%
存储：Store at -20°C

Background:

T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes[1].

T-26c significantly inhibits the breakdown of collagen (87.4% inhibition at 0.1 μM) in IL-1β and oncostatin M stimulated cartilage[1].

[1]. Nara H, et al. Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1″ binding site. Bioorg Med Chem. 2014 Oct 1;22(19):5487-505.