Pelitrexol is a GARFT inhibitor, and is also a water soluble antifolate with anti-proliferative activity. Pelitrexol inhibits activity of glycinamide ribonucleotide formyltransferase (GARFT), the first folate-dependent enzyme of the de novo purine synthesis pathway essential for cell proliferation. Enzyme inhibition reduces the purine nucleotides pool required for DNA replication and RNA transcription. As a result, this agent causes cell cycle arrest in S-phase, and ultimately inhibits tumor cell proliferation. References: 1. Frost, Gregory I.; Jiang, Ping; Thompson, Curtis B. Modified hyaluronidases and uses in treating hyaluronan-associated diseases and conditions. PCT Int. Appl. (2009), 292 pp. CODEN: PIXXD2 WO 2009128917 A2 20091022 CAN 15462825 AN 2009:1297488

纯度：≥98%

CAS：446022-33-9