Raloxifene 4'-glucuronide is a metabolite of the selective estrogen receptor modulator raloxifene.
CAS：182507-22-8
分子式：C34H35NO10S
分子量：649.7
纯度：98%
存储：Store at -20°C

Background:

Raloxifene 4’-glucuronide is a metabolite of the selective estrogen receptor modulator raloxifene . It is formed from raloxifene via the UDP-glucuronosyltransferase (UGT) isoforms UGT1A1, UGT1A8, and UGT1A10. It binds to the estrogen receptor with an IC50 value of 370 nM. Raloxifene 4’-glucuronide inhibits the voltage-gated potassium channel Kv4.3 by 6.2 and 20.1% when used at concentrations of 10 and 30 µM, respectively.