Heat shock protein 90 (Hsp90) is a molecular chaperone that modulates intracellular signaling and protein folding, trafficking, and turnover.
CAS：1012788-65-6
分子式：C19H20ClN3O4
分子量：389.8
纯度：98%
存储：Store at -20°C

Background:

Heat shock protein 90 (Hsp90) is a molecular chaperone that modulates intracellular signaling and protein folding, trafficking, and turnover. Inhibitors of Hsp90, such as geldanamycin, have shown promise as anti-tumor agents. Benzisoxazole Hsp90 inhibitor binds the N-terminal domain of Hsp90, efficiently displacing geldanamycin from the ATP binding site (IC50 = 30 nM). In addition, Benzisoxazole Hsp90 inhibitor inhibits the proliferation of several cancer cell lines (IC50