Ogerin是一种选择性的GPR68正向别构调节剂，pEC50值为6.83。Ogerin对A2A受体具有适中的拮抗作用，Ki值为220nM；对5-HT2B受体的拮抗作用较弱，Ki值为736nM。Ogerin抑制小鼠对恐惧记忆的回忆。
CAS：1309198-71-7
分子式：C17H17N5O
分子量：307.35
纯度：98%
存储：Store at -20°C

Background:

Ogerin is a selective GPR68 positive allosteric modulator, with a pEC50 of 6.83. Ogerin shows inverse agonist and antagonist activity (Ki, 220 nM) at A2A receptoor and weak antagonist activity (Ki, 736 nM) at 5-HT2B receptor. Ogerin blocks recall in fear conditioning in mice[1]. pEC50: 6.83 (GPR68)[1]Ki: 220 nM (A2A receptoor), 736 nM (5-HT2B receptor)[1]

[1]. Huang XP, et al. Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65. Nature. 2015 Nov 26;527(7579):477-83.