Tubulin polymerization inhibitor
CAS：154554-41-3
分子式：C16H10FNO3
分子量：283.25
纯度：98%
存储：Store at -20°C

Background:

Inducer of apoptosis; displays potent antitumor ability in human hepatocellular carcinoma. Inhibits tubulin polymerizationin vitroandin vivo. Causes cell cycle arrest at G₂/M phase by activation of Cdc2 kinase activity. Induces translocation of apoptosis inducing factor (AIF) from the mitochondria to nucleus. Also exhibits vascular targeting activity through upregulation of p53 and induction of death receptor (DR5)-mediated apoptosis in HUVEC cells.