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(-)-MK 801
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(-)-MK 801图片
CAS NO:121917-57-5
规格:98%
分子量:221.3
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
NMDA antagonist,potent and selective
CAS:121917-57-5
分子式:C16H15N
分子量:221.3
纯度:98%
存储:Store at -20°C

Background:

(+)-MK 801 Maleate is a potent antagonist of NMDA with Ki value of 30.5nM [1].


MK 801 is a potent anticonvulsant exhibits both anxiolytic and sympathomimetic properties. It is found to be a noncompetitive antagonist of NMDA. MK 801 can penetrate into the central nervous system. In the in vitro assay, MK 801 binds to rat cerebral cortical membrane with high affinity in a saturable manner. This binding is reversible even when the concentration of MK 801 is up to 100μM. It is also found that the binding shows a regional specificity. Most of these binding sites are located in the hippocampus. In rat cortical-slice preparations, MK 801 causes a potent blockade of depolarizing responses to NMDA with a high selectivity. This effect is persistent. The blockade can also cause a suppression of the epileptiform activity induced by tetrodotoxin or other neurotoxin [1].


参考文献:
[1] Wong EH, Kemp JA, Priestley T, Knight AR, Woodruff GN, Iversen LL . The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist. Proc Natl Acad Sci U S A. 1986 Sep;83(18):7104-8.