您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > PC-766B
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
PC-766B
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PC-766B图片
CAS NO:108375-77-5
规格:98%
分子量:777
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
macrolide antibiotic
CAS:108375-77-5
分子式:C43H68O12
分子量:777
纯度:98%
存储:Store at -20°C

Background:

PC-766B is a macrolide antibiotic existed in anactinomycete strain SC-4710.


PC-766B was active against Gram-positive bacteria, and some fungi and yeasts, yet inactive against Gram-negative bacteria. PC-766B exhibited potent cytotoxicity against murine tumor cell lines in vitro. The IC50 values against P388 leukemia and B16 melanoma were 0.1 and 0.5 ng/ml, respectively [1]. Intraperitoneal administration of PC-766B (0.25mg/kg/day) showed in vivo antitumor activity against P388 leukemia. PC-766B showed a weak inhibitory activity against Na+, K+-ATPase [1].


Reference:
[1] KUMAGAI K, TAYA K, FUKUI A, et al.  PC-766B, A NEW MACROLIDE ANTIBIOTIC PRODUCED BY Nocardia brasiliensis[J]. The Journal of antibiotics, 1993, 46(6): 972-978.