Idalopirdine (Lu AE58054) 是有效，选择性的 5-HT6 受体拮抗剂，Ki 为 0.83 nM。
CAS：467459-31-0
分子式：C20H19F5N2O
分子量：398.37
纯度：98%
存储：Store at -20°C

Background:

Idalopirdine (Lu AE58054) is a potent and selective 5-HT6 receptor antagonist with a Ki of 0.83 nM.

[1]. Arnt J, Bang-Andersen B, Grayson B, Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats. Int J Neuropsychopharmacol. 2010 Sep;13(8):1021-33. [2]. Witten L, Bang-Andersen B, Nielsen SM, Characterization of [•H]Lu AE60157 ([•H]8-(4-methylpiperazin-1-yl)-3-phenylsulfonylquinoline) binding to 5-hydroxytryptamine• (5-HT•) receptors in vivo.Eur J Pharmacol. 2012 Feb 15;676(1-3):6-11.