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Angiotensin II(5-8)(human,rat,mouse)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Angiotensin II(5-8)(human,rat,mouse)图片
CAS NO:34233-50-6
包装:1mg
规格:98%
市场价:1114元
分子量:512.6

产品介绍
Angiotensin II (5-8) is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II.
CAS:34233-50-6
分子式:C26H36N6O5
分子量:512.6
纯度:98%
存储:Store at -20°C

Background:

Angiotensin II (5-8) is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II . It inhibits renin release from rat kidney slices at a concentration of 50 μM and relaxes rat aorta pre-contracted with phenylephrine . In vivo, microinjection of angiotensin II (5-8) into the ventrolateral periaqueductal gray (vlPAG) of rats increases mean arterial pressure (MAP) and decreases heart rate (HR) by approximately 2.7- and 3-fold less, respectively, than angiotensin II. It increases the latency to withdrawal in a tail-flick test and the mechanical withdrawal threshold in an incision allodynia test in rats when administered at a dose of 0.2 nmol into the vlPAG. Angiotensin II (5-8) (0.4 nmol, vlPAG microinjection) reduces the number of entries and time spent in the open arms of the elevated plus maze and increases the mean startle amplitude, a measure of conditioned fear, in response to foot shock.