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(E)-5-(2-Bromovinyl)uracil
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(E)-5-(2-Bromovinyl)uracil图片
CAS NO:69304-49-0
规格:98%
分子量:217
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
250mg电议

产品介绍
(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo.
CAS:69304-49-0
分子式:C6H5BrN2O2
分子量:217
纯度:98%
存储:Store at -20°C

Background:

(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2’-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil in a P388 murine leukemia model when administered at a dose of 200 µmol/kg, increasing survival time.