Acetyldigitoxin is cardiac glycoside and an inhibitor of the Na+/K+ ATPase with an IC50 value of 5 nM in isolated rat pinealocytes.
CAS:1111-39-3
分子式:C43H66O14
分子量:807
纯度:98%
存储:Store at -20°C
Background:
Acetyldigitoxin is cardiac glycoside and an inhibitor of the Na+/K+ ATPase with an IC50 value of 5 nM in isolated rat pinealocytes. This inhibition results in loss of the transmembrane Na+ gradient, which decreases activity of the Na+/Ca2+ exchanger, increasing intracellular calcium levels, inotropy, and cardiac force. Formulations containing acetyldigitoxin have been used for the treatment of heart failure and chronic atrial fibrillation.