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Naspm trihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Naspm trihydrochloride图片
CAS NO:1049731-36-3
包装:10mg
规格:98%
市场价:1599元
分子量:479.91

产品介绍
Ca2+-permeable AMPA receptor antagonist
CAS:1049731-36-3
分子式:C22H34N4O.3HCl
分子量:479.91
纯度:98%
存储:Store at -20°C

Background:

Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.


NASPM selectively suppresses the inwardly rectifying and Ca2+-permeable AMPA receptors expressed in type II neurons. It has no effect on AMPA receptors in type I neurons. At -60 mV, NASPM suppresses AMPA receptors in type II neurons with an IC50 value of 0.33 μM. The blocking effect of NASPM on the Ca2+-permeable AMPA receptors is use and voltage-dependent[1].


参考文献:
[1]. Koike M, et al. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci Res. 1997 Sep;29(1):27-36.