您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > GLX351322
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
GLX351322
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GLX351322图片
CAS NO:835598-94-2
规格:98%
分子量:431.51
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
GLX351322是一种NADPH氧化酶4(NADPHoxidase4)抑制剂,在NOX4过表达的细胞中,抑制过氧化氢的产生,IC50值为5μM。
CAS:835598-94-2
分子式:C21H25N3O5S
分子量:431.51
纯度:98%
存储:Store at -20°C

Background:

GLX351322 is an inhibitor of NADPH oxidase 4, and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μ M.


GLX351322 is an inhibitor of NADPH oxidase 4, and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μM. GLX351322 shows weak activity against NOX2 in hPBMC cells (IC50, 40 μM).


GLX351322 (3.8 mg/kg/day, p.o.) ameliorates HFD-induced hyperglycemia in mice[1].


[1]. Anvari E, et al. The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice. Free Radic Res. 2015;49(11):1308-18.